"AntiEstrogens". Sophie Dauvois and Malcolm G. Parker Introduction The
estrogen receptor belongs to a large family of nuclear receptors whose activity as
a transcription factor depends on the binding of a hormonal ligand (1). As with
other steroid receptors, in the absence of ligand the estrogen receptor is found in
an oligomeric complex that is unable to bind to DNA (2-4). Following hormone
binding, the complex is dissociated to al ..."