"This second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity studies by using in vitro, ex vivo, and in vivo models."
""This book focuses on recently developed High-Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in vivo assays, and computational techniques to analyse HTS data are all examined."--Back cover."
"This book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in vivo assays, and computational techniques to analyze HTS data are all examined. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their resp ..."
"This second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity studies by using in vitro, ex vivo, and in vivo models."
"Discussion. Here, we describe a successful machine learning method for the
prediction of different outcomes of the nuclear receptor and stress response
pathway screening from the Tox21 Data Challenge 2014. The key to our method
is the combination of different molecular fingerprints and descriptors as well as
the integration of two different algorithms, a similarity-based approach and a
naïve Bayes machine learning technique. Combin ..."