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  | | Hormonal Carcinogenesis II Proceedings of the Second International Symposium by Jonathan J. Li, Sara A. Li, Jan-Ake Gustafsson, Satyabrata Nandi, Lea I. Sekely 500 Pages, Published 2012 by Springer Science & Business Media ISBN-13: 978-1-4612-2332-0, ISBN: 1-4612-2332-6 "AntiEstrogens". Sophie Dauvois and Malcolm G. Parker Introduction The estrogen receptor belongs to a large family of nuclear receptors whose activity as a transcription factor depends on the binding of a hormonal ligand (1). As with other steroid receptors, in the absence of ligand the estrogen receptor is found in an oligomeric complex that is unable to bind to DNA (2-4). Following hormone binding, the complex is dissociated to al ..." |
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Jan-Ake Gustafsson