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Reducing, Refining and Replacing the Use of Animals in Toxicity Testing(1st Edition)
RSC (Issues in Toxicology)
by Mike D. Waters, Dave Allen, Martin L. Stephens, Leslie Recio, Hao Zhu, Nathalie Alepee, Darrell R. Boverhof, John R. Fowle, Jon Richmond, Rodger Curren, David Basketter, Andreas Natsch, Charles Eldridge, Christopher J. Borgert, Errol Zeiger, Alberto Mantovani, Chantra Eskes, David Andrew, David G. Allen, Waters Allen
Hardcover, 362 Pages, Published 2013 by Royal Society Of Chemistry
ISBN-13: 978-1-84973-652-7, ISBN: 1-84973-652-9

"Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the en ..."

Validation of Alternative Methods for Toxicity Testing(Softcover reprint of the original 1st ed. 2016)
(Advances in Experimental Medicine and Biology)
by Chantra Eskes, Maurice Whelan
Paperback, 427 Pages, Published 2017 by Springer
ISBN-13: 978-3-319-81612-8, ISBN: 3-319-81612-8

Validation of Alternative Methods for Toxicity Testing(1st Edition)
(Advances in Experimental Medicine and Biology)
by Chantra Eskes, Maurice Whelan
Hardcover, 407 Pages, Published 2016 by Springer
ISBN-13: 978-3-319-33824-8, ISBN: 3-319-33824-2

"This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway ..."

Alternatives for Dermal Toxicity Testing(1st Edition)
by Chantra Eskes, Erwin Van Vliet, Howard I. Maibach
Hardcover, 586 Pages, Published 2017 by Springer
ISBN-13: 978-3-319-50351-6, ISBN: 3-319-50351-0

"This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage ..."

Alternatives for Dermal Toxicity Testing
by Chantra Eskes, Erwin Van Vliet, Howard I. Maibach
592 Pages, Published 2017 by Springer
ISBN-13: 978-3-319-50353-0, ISBN: 3-319-50353-7

"Chantra Eskes, Erwin van Vliet, Howard I. Maibach. Rico Brendtke, Bart De Wever, Florian Groeber, Jan Hansmann, Freia Schmid, and Heike Walles 42.1 State of the Art of High-Throughput Screening High-throughput screening (HTS) is a technique well known for the identification of hits in drug discovery [1–3]. For the selection of promising lead candidates, thousands of molecules have to be tested [4]. Therefore, the automation of the ..."

Validation of Alternative Methods for Toxicity Testing
by Chantra Eskes, Maurice Whelan
407 Pages, Published 2016 by Springer
ISBN-13: 978-3-319-33826-2, ISBN: 3-319-33826-9

"Most HTAs are performed using highly automated processes developed on custom-built robotic platforms and are therefore ... Transferability, one of the assessments of reliability along with inter-laboratory repeatability, is important because (i) it provides ... Since many HTAs are adapted from previously existing lowthroughput methods (i.e. manual protocols), the most ... biological pathway may be useful in confirming or at least s ..."

Alternatives for Dermal Toxicity Testing(Softcover reprint of the original 1st ed. 2017)
by Eskes, Chantra, van Vliet, Erwin, Maibach, Howard I.
612 Pages, Published 2018 by Springer
ISBN-13: 978-3-319-84378-0, ISBN: 3-319-84378-8

Books by Chantra Eskes