"Billions of dollars are spent every year on research into targeted therapies for cancer. That's why it's more than ever crucial for the thousands of scientists working in the field to keep right up to date with the cutting edge. This fascinating collection of material goes a long way to helping them do so, featuring as it does contributions to a crucial international meeting in Italy. The meeting provided a f ..."
"Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and in host defense and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious disease ..."
"Billions of dollars are spent every year on research into targeted therapies for cancer. That's why it's more than ever crucial for the thousands of scientists working in the field to keep right up to date with the cutting edge. This fascinating collection of material goes a long way to helping them do so, featuring as it does contributions to a crucial international meeting in Italy. The meeting provided a f ..."
"A. Kortenkamp, Ten years of mixing cocktails: A review of combination effects of endocrine-disrupting chemicals, Environ. Health Perspect., 2007, DOI: 10.1289/ehp.9357. 3. A. Kortenkamp, Low dose mixture effects of endocrine disrupters: ..."
"This compilation examines the defensive role of cellular and cytokine networks responding to injury, infection or inflammation of different tissue, such as the brain, epithelium, intestinal tract and respiratory tract. It covers the complex actions of diverse cytokines, including human interleukin-9, interleukin-11, NADPH oxidase, human interferon-gamma receptor and interleukin-10."
Tumor-Associated Leukocytes Pathophysiology and Therapeutic Applications (Molecular Biology Intelligenc Unit) by AlbertoMantovani Hardcover, 106 Pages, Published 1994 by R G Landes Co ISBN-13: 978-1-57059-013-9, ISBN: 1-57059-013-3
""Tumor-Associated Leukocytes" discusses leukocyte infiltration of neoplastic tissue. It also reviews the pathology and molecular mechanisms of leukocyte infiltration of tumours. Since tumour associated leukocytes are strategically located at the interface-between tumour and host, they represent targets for therapeutic intervention. Current therapeutic strategies and future prospects, including targeted cytokine immunotherapy, gene thera ..."
Macrophages Biology and Role in the Pathology of Diseases by Subhra K. Biswas, AlbertoMantovani Hardcover, 615 Pages, Published 2014 by Springer ISBN-13: 978-1-4939-1310-7, ISBN: 1-4939-1310-7
"Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morpho ..."
Macrophages(Reprint) Biology and Role in the Pathology of Diseases by Subhra K. Biswas, AlbertoMantovani Paperback, 615 Pages, Published 2016 by Springer ISBN-13: 978-1-4939-5487-2, ISBN: 1-4939-5487-3
"Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morpho ..."
"Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and inhost defense and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases ..."
Macrophages Biology and Role in the Pathology of Diseases by Subhra K. Biswas, AlbertoMantovani 615 Pages, Published 2014 by Springer ISBN-13: 978-1-4939-1311-4, ISBN: 1-4939-1311-5
"Sandra E. Nicholson and Peter J. Murray. 24.1. Introduction. What is macrophage
polarization? How does STAT–Suppressors Of Cytokine Signaling (SOCS)
signaling regulate polarization? The goal of this review is to summarize current
knowledge pertinent to the second question. However, before we review the
complex cytokine-driven processes that both promote and then feedback to
inhibit polarization, we need to address the first questio ..."
"Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the en ..."
"VEGF is a potent angiogenic factor as well as a monocyte attractant that
contributes to TAM recruitment. TAM promote angiogenesis and there is
evidence that inhibition of TAM recruitment plays an important role in
antiangiogenic strategies. We found that, in addition to VEGF, the angiogenic
program established by hypoxia may rely also on the increased expression of
CXCR4 by TAM and endothelial cells [138]. Intratumoral injection of ..."
"The text here offers readers an overview of diverse approaches, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality."
"After Phase I and II studies had suggested important activity for Sunitinib in GIST
patients failing Imatinib or being intolerant ... in a 2:1 randomization (Demetri,
Van Oosterom, Garrett, Blackstein, Shah, Verweij, McArthur, Judson, Heinrich,
Morgan, ... What the data on Sunitinib also show is that there may be a whole
range of other options for treatment of GIST. ... Interestingly, this has not only lead
to better results, but e ..."
"Today, we are surrounded by a multitude of different chemicals that are essential components of our everyday life. As a consequence, there are various hazardous substances like dioxins, phthalates and flame-retardants circulating in the environment. These have an impact on ecosystems, wildlife and possibly human health. In recent years, the phenomenon called endocrine disruption has raised considerable concern. This book discusses the s ..."
Chemokines(1st Edition) by AlbertoMantovani, H. Renz Hardcover, 208 Pages, Published 1999 by S. Karger ISBN-13: 978-3-8055-6861-6, ISBN: 3-8055-6861-4
"Chemokines are a superfamily of small proteins which play a crucial role in immune and inflammatory reactions and in viral infection. They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system. This book provides an overview of the main structural and functional features of chemokines. It presents recent studies which indicate that chemokines regulate th ..."
"L’opera tratta la storia, attraverso sia il racconto che le numerose immagini (288 a colori, 4 in bianco e nero), delle quattro Ferrari stradali turbocompresse otto cilindri degli anni ’80: dalla 208 turbo alla F40, con cenni anche alle vetture di Formula 1 da cui questi modelli discendono. Inizia con illustrare la genesi della gamma Ferrari ad otto cilindri con motore centrale, quindi le modalità e motivazioni del loro passaggio alla s ..."