Cancer Immunotherapy Chapter 27. Tumor-associated Macrophages in Cancer Growth and Progression by Alberto Mantovani, Maria Rosaria Galdiero, PaolaAllavena, Antonio Sica 684 Pages, Published 2013 by Elsevier Inc. Chapters ISBN-13: 978-0-12-805923-4, ISBN: 0-12-805923-0 "VEGF is a potent angiogenic factor as well as a monocyte attractant that
contributes to TAM recruitment. TAM promote angiogenesis and there is
evidence that inhibition of TAM recruitment plays an important role in
antiangiogenic strategies. We found that, in addition to VEGF, the angiogenic
program established by hypoxia may rely also on the increased expression of
CXCR4 by TAM and endothelial cells [138]. Intratumoral injection of ..."
