Macrophages Biology and Role in the Pathology of Diseases by Subhra K. Biswas, AlbertoMantovani 615 Pages, Published 2014 by Springer ISBN-13: 978-1-4939-1311-4, ISBN: 1-4939-1311-5
"Sandra E. Nicholson and Peter J. Murray. 24.1. Introduction. What is macrophage
polarization? How does STAT–Suppressors Of Cytokine Signaling (SOCS)
signaling regulate polarization? The goal of this review is to summarize current
knowledge pertinent to the second question. However, before we review the
complex cytokine-driven processes that both promote and then feedback to
inhibit polarization, we need to address the first questio ..."
"VEGF is a potent angiogenic factor as well as a monocyte attractant that
contributes to TAM recruitment. TAM promote angiogenesis and there is
evidence that inhibition of TAM recruitment plays an important role in
antiangiogenic strategies. We found that, in addition to VEGF, the angiogenic
program established by hypoxia may rely also on the increased expression of
CXCR4 by TAM and endothelial cells [138]. Intratumoral injection of ..."
"After Phase I and II studies had suggested important activity for Sunitinib in GIST
patients failing Imatinib or being intolerant ... in a 2:1 randomization (Demetri,
Van Oosterom, Garrett, Blackstein, Shah, Verweij, McArthur, Judson, Heinrich,
Morgan, ... What the data on Sunitinib also show is that there may be a whole
range of other options for treatment of GIST. ... Interestingly, this has not only lead
to better results, but e ..."
"GongJ, Wei T, Stark RW, Jamitzky F, Heckl WM, Anders HJ, et al. Inhibition of toll-
like receptors TLR4 and 7 signaling pathways by SIGIRR: a computational
approach. J Struct Biol (2010) 169:323–30. doi:10.1016/j.jsb.2009.12.007
Drexler SK, Kong P, Inglis J, Williams RO, Garlanda C, Mantovani A, et al.
SIGIRR/TIR-8 is an inhibitor of toll-like receptor signaling in primary human cells
and regulates inflammation in models of rheumato ..."