Macrophages Biology and Role in the Pathology of Diseases by Subhra K. Biswas, AlbertoMantovani Hardcover, 615 Pages, Published 2014 by Springer ISBN-13: 978-1-4939-1310-7, ISBN: 1-4939-1310-7
"Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morpho ..."
Macrophages Biology and Role in the Pathology of Diseases by Subhra K. Biswas, AlbertoMantovani 615 Pages, Published 2014 by Springer ISBN-13: 978-1-4939-1311-4, ISBN: 1-4939-1311-5
"Sandra E. Nicholson and Peter J. Murray. 24.1. Introduction. What is macrophage
polarization? How does STAT–Suppressors Of Cytokine Signaling (SOCS)
signaling regulate polarization? The goal of this review is to summarize current
knowledge pertinent to the second question. However, before we review the
complex cytokine-driven processes that both promote and then feedback to
inhibit polarization, we need to address the first questio ..."
"VEGF is a potent angiogenic factor as well as a monocyte attractant that
contributes to TAM recruitment. TAM promote angiogenesis and there is
evidence that inhibition of TAM recruitment plays an important role in
antiangiogenic strategies. We found that, in addition to VEGF, the angiogenic
program established by hypoxia may rely also on the increased expression of
CXCR4 by TAM and endothelial cells [138]. Intratumoral injection of ..."
"Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the en ..."
"Today, we are surrounded by a multitude of different chemicals that are essential components of our everyday life. As a consequence, there are various hazardous substances like dioxins, phthalates and flame-retardants circulating in the environment. These have an impact on ecosystems, wildlife and possibly human health. In recent years, the phenomenon called endocrine disruption has raised considerable concern. This book discusses the s ..."