| | The Cellular Response to the Genotoxic Insult(1st Edition) The Question of Threshold for Genotoxic Carcinogens (Issues in Toxicology) by Helmut Greim, Richard J. Albertini, Mathieu Vinken, Lutz Mueller, Boris Zhivotovski, Grigory Dianov, Hermann M. Bolt, Susan Wallace, Diana Anderson, Eugenia Dogliotti, B. Kaina, Gary Williams, M. Ljungman, W. Dekant, R. J. Preston, P.C. Hanawalt, Tim Marrs, Mike D. Waters Hardcover, 334 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-177-5, ISBN: 1-84973-177-2
"Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challeng ..."
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