"Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods• Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects• Contains both in vitro and in vivo ..."
"This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative re ..."
"This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice."
"... A., Haltner-Ukaomadu, E., Kaca, M., Kamp, H., Kietzmann, M., Korting, H.C.,
Krachter, H.-U., Lehr, C.M., Liebsch, M., Mehling, A., Netzlaff, F., Niedorf, F.,
Rübbelke, M.K., Schäfer, U., Schmidt, E., Schreiber, S., Schroder, K.-R.,
Spielmann, H., Vuia, A. (2006) Reconstructed human epidermis for skin
absorption testing: results of the German prevalidation study. ATLA, 34, 283–294.
Schäfer-Korting, M., Bock, U., Diembeck, W., Dü ..."
Drug-Induced Liver Toxicity(1st Edition) (Methods in Pharmacology and Toxicology) by Minjun Chen, YvonneWill Hardcover, 667 Pages, Published 2018 by Humana ISBN-13: 978-1-4939-7676-8, ISBN: 1-4939-7676-1
"This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help ..."
"This book provides an integrated review and assessment of the tools and methods for safety toxicology studies performed at each stage of the pre-clinical drug development process. The authors, writing from firsthand industry experience, give readers insight into the strategy and execution of predictive toxicology practices, including what experiments are possible and useful. In addition, they offer a view into the future, indicating key ..."
"... P., H. Pi, S. Xu, L. Zhang, Y. Li, M. Li, Z. Cao, L. Tian, J. Xie, R. Li, M. He, Y. Lu,
C. Liu, W. Duan, Z. Yu, and Z. Zhou (2014). ... Cell surface oxygen consumption:
A major contributor to cellular oxygen consumption in glycolytic cancer cell lines."
"40. 41. 42. 43. Sandri G, Panfili E, Ernster L. Hydrogen peroxide production by
monoamine oxidase in isolated rat-brain mitochondria: its effect on glutathione
levels and Ca2+ efflux. ... Pacher P, Beckman JS, Liaudet L. Nitric oxide and
peroxynitrite in health and disease. Physiol Rev. ... Perez-Ortiz JM, Tranque P,
Burgos M, Vaquero CF, Llopis J. Glitazones induce astroglioma cell death by
releasing reactive oxygen species from m ..."
"Modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of great importance. Such approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technolog ..."
Depression(4th Edition) Psychodynamik und Therapie. Herbert Will, Yvonne Grabenstedt, Günter Völkl, Gudrun Banck; mit einem Beitrag von Günter Klug und Dorothea Huber / Psychoanalytische Krankheitslehre by Herbert Will, Gudrun Banck, Yvonne Grabenstedt, Gunter Volkl, Wolfgang Mertens Paperback, 261 Pages, Published 2019 by W. Kohlhammer Gmbh ISBN-13: 978-3-17-032978-2, ISBN: 3-17-032978-2
Slaves of a Different Kind Unshackling Our Soul to Heal America by Yvonne G. Williams Paperback, 326 Pages, Published 2015 by Raise The Bar Productions ISBN-13: 978-0-692-33610-6, ISBN: 0-692-33610-9
"Somewhere in between all the creeds and dogmas of faith lies a beautiful place of human compassion and the ability to relate to one another on the same level. There are many that have a genuine love for the people of the United States and long to see better days but standing in the way of fulfillment lies a sense of entitlement that exists as a cancer upon the collective American soul that divides us from the equality inherent to us as ..."