"Multivariate (MV) analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens provides a 'fingerprint' of their biomolecular/metabolic status and hence, when correctly applied, much valuable information regarding disease indicators, disease strata and sub-strata, and disease activities. These techniques serve as powerful tools for clinical and toxicological research, including drug ..."
"Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming profe ..."
"Advances in Dermatological Sciences collates major scientific research achievements over the last two years in a diverse range of dermatological research fields. Examples of key topics covered include experimental models, toxicology, regulatory, exposure assessment, therapeutics, cosmetics and decontamination. A unique feature of the book is the introductory chapter to each section that is written by an internationally-recognised expert ..."
"Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming profe ..."
"Although it is widely recognized that environmental factors such as smoking, diet, exercise, and socioeconomic status affect the risk of cardiovascular disease, recent work showing the effects of other environmental factors provides a more complete assessment of the situation. This view has emerged from three developments. Firstly, there has been a sudden explosion in the prevalence of diabetes and obesity which indicates a strong envir ..."
"The vast number of chemicals existing or being added into the environment, have globally aroused great concern regarding their adverse effects in human population. Development and validation of sensitive and better test systems which can assess the adverse effects of chemicals at an early stage for intervention strategies to be implemented in time is currently in progress. This book documents the latest research and showcases the versat ..."
"Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming profe ..."
"Multivariate analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens can provide a 'fingerprint' of their biomolecular/metabolic status. Therefore, if applied correctly, valuable information regarding disease indicators, disease strata and sub-strata and disease activities can be obtained. This exemplary new book highlights applications of these techniques in the areas of drug ..."
"The text will be essential reading for interdisciplinary scientists working in dermal pharmacology, dermatological and dermatotoxicological sciences."
"Advances in Dermatological Sciences is a three-volume set that collates major scientific research achievements over the last two years in a diverse range of dermatological research fields. Examples of key topics covered over all three volumes include experimental models, toxicology, regulatory, exposure assessment, therapeutics, cosmetics and decontamination. A unique feature of the books is the introductory chapter to each section that ..."
"The world's aging populations, with age-related disorders affecting every organ system, are generating medical care costs rising at an unsustainable rate. Although such disorders are expected, we are now beginning to ask whether exposures to toxic environmental chemicals hasten or account for their onset. This book provides a detailed review of current knowledge about the possible associations between a variety of chemical contaminants ..."
"The aim of this book is to provide the scientific background to using the formation of chemical categories, or groups, of molecules to allow for read-across i.e. the prediction of toxicity from chemical structure. It covers the scientific basis for this approach to toxicity prediction including the methods to group compounds (structural analogues and / or similarity, mechanism of action) and the tools to achieve this. The approaches to ..."
"Human biomonitoring has developed from a research tool in occupational and environmental health to identify and quantify exposures to harmful substances in urine and blood. The analytical methods for detection of substances in biological media have considerably improved with smaller detection limits and more precise and specific measurements. Human biomonitoring is a valuable tool in exposure estimation of selected populations and curre ..."
"Silver in healthcare has many different facets and since the early concepts of microbiology of the 1880's, has been developed from usage in surgical clips, staples, foil wound dressings and surgical implants, to the widespread and clinically effective antiseptic wound dressings, sutures, catheters, bone and dental implants, and cardiovascular devices of today. From the dawn of human civilisation, silver has had a role of water purificat ..."
"Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to cancer. They have evolved exquisite mechanisms for controlling their own synthesis and to ensure that they are ..."
"The issue of male germ line mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile over recent years. Mutations are thought to be becoming more prevalent as a result of: exposure to chemicals in the environment, anti cancer regimes that use genotoxic agents and assisted conception techniques. In addition to the increasing frequency of mutations in the general population, attent ..."
"This book discusses omics technologies and their potential for understanding the actions of toxins on the environment and living organisms. Such approaches provide a snapshot of organismic and cellular responses that can be analyzed at both the population and individual level. Each omics technology (metabolomics, transcriptomics, proteomics, genomics and epigenomics) is discussed in terms of usage methodologies, potential application ..."
"The world's aging populations, with age-related disorders affecting every organ system, are generating medical care costs rising at an unsustainable rate. Although such disorders are expected, we are now beginning to ask whether exposures to toxic environmental chemicals hasten or account for their onset. This book provides a detailed review of current knowledge about the possible associations between a variety of chemical contaminants ..."
"Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challeng ..."