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  | | (1st Edition) by Jesus Avila, Felix Hernandez, Ana Martinez, Jose J. Lucas, Akihiki Takashima, Jurgen Gotz, Leonidas Stefanis, Eduardo Soriano, Frank M. Laferla, Toru Takumi, Maria Gasset, Jose Lopez-Barneo, David C. Henshall, Inge Grundke-Iqbal, José González Castaño, David E. Thurston, Rsc Publishing Hardcover, 306 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-184-3, ISBN: 1-84973-184-5 "In recent years, medical developments have resulted in an increase in human life expectancy. Some developed countries now have a larger population of individuals aged over 64 than those under 14. One consequence of the ageing population is a higher incidence of certain neurodegenerative disorders. In order to prevent these, we need to learn more about them. This book provides up-to-date information on the use of transgenic mouse models ..." |
 | | Neglected Diseases and Drug Discovery(1st Edition) RSC (RSC Drug Discovery) by Michael J. Palmer, Jonathan Vennerstrom, Meg Phillips, Arnab Chatterjee, Simon Croft, Bob Jacobs, John Overington, Debra Hanna, Thomas Keller, Tim Geary, Elna Ryst, David Brown, Win Gutteridge, Simon Campbell, Jeremy N. Burrows, Mark Mitton-Fry, J. Carl Craft, David Fox, Mike Palmer, Rsc Publishing, Ana Martinez, David E. Thurston, Salvatore Guccione, David P. Rotella, Professor Robin Ganellin 438 Pages, Published 2012 by Rsc ISBN-13: 978-1-84973-192-8, ISBN: 1-84973-192-6 "There are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas th ..." |
 | | G Protein-Coupled Receptors(1st Edition) From Structure to Function (RSC Drug Discovery) by Jesus Giraldo, Jean-Philippe Pin, Krzysztof Palczewski, Gebhard Schertler, Ana Martinez, Francisco Ciruela, Stefano Costanzi, Marta Filizola, Michel Bouvier, Debbie Hay, Terry Kenakin, Martin Lohse, Vsevolod V. Gurevich, Joël Bockaert, Pablo Escribá, Jean-Pierre Vilardaga, Thomas P. Sakmar, Robert J. Lefkowitz, Federico Mayor Jnr, Milton T. Stubbs, Jonathon A. Javitch, Oliver P. Ernst, Jennifer Linderman, Roger Sunahara, Graeme Milligan, Steven O. Smith, David E. Shaw, David E. Thurston, Franciso Ciruela, Dr. Jean-Pierre Vilardaga, Rsc Publishing, Pablo V. Escribß, Jane Doe, Joùl Bockaert, Casanelia L. Hardcover, 548 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-183-6, ISBN: 1-84973-183-7 "G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, pept ..." |
 | | Accounts in Drug Discovery(1st Edition) Case Studies in Medicinal Chemistry (RSC Drug Discovery) by Joel C. Barrish, Percy H. Carter, Robert Zahler, Peter Cheng, Bruce Rogers, Christopher Barber, Jeffrey Robl, Mark Norman, Lyn Jones, Gavin Whitlock, Mark Andrews, Mark Mulvihill, Richard Mackman, Edmund Graziani, Phil Hamann, Mike Sofia, Samuel Chackalamannil, Ramakanth Sarabu, David P. Rotella, Michael J. Palmer, Ashvinikumar V. Gavai, David Fox, Ana Martinez, Salvatore Guccione, David E. Thurston, Rsc Publishing Hardcover, 370 Pages, Published 2010 by Royal Society Of Chemistry ISBN-13: 978-1-84973-126-3, ISBN: 1-84973-126-8 "Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" ..." |
 | | Emerging Drugs and Targets for Alzheimer's Disease(1st Edition) Volume 2: Neuronal Plasticity (Drug Discovery) by Ana Martinez, Rsc Publishing, David E. Thurston Hardcover, 326 Pages, Published 2010 by Royal Society Of Chemistry ISBN-13: 978-1-84973-064-8, ISBN: 1-84973-064-4 "Alzheimer's disease is the most prevalent neurodegenerative disorder in the elderly. A recent study from the Bloomberg School of Public Health recently estimated that over 26 million people were living with the disease in 2006 and that the global prevalence of the disease will grow to 106 million by 2050. By that time, 43 per cent of those living with the disease will need high-level care, equivalent to that of a nursing home. However, ..." |
 | | Pharmaceutical Salts and Co-crystals(1st Edition) RSC (RSC Drug Discovery) by Johan Wouters, Andrew Bond, Mike Zaworotko, Gerard Coquerel, Rolf Hilfiker, Timo Rager, Bill Jones, Lori Hilden, Anaelle Tilborg, Laszlo Fabian, Hassa Jurgen, Gautam Desiraju, Nilanjana Biswas, Nathan Schultheiss, Luc Quéré, François Puel, David E. Thurston, Nair Rodriguez-Hornedo, F. Jj Leusen, Camille Georges Wermuth, Rsc Publishing, Ana Martinez, Michael Zaworotko, David Fox, Salvatore Guccione, David P. Rotella, Professor Robin Ganellin, Franþois Puel, Luc Quuru, Fran Ois Puel, Franois Puel Hardcover, 406 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-158-4, ISBN: 1-84973-158-6 "From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book_ entirely dedicated to ..." |
 | | Pharmaceutical Process Development(1st Edition) Current Chemical and Engineering Challenges (RSC Drug Discovery) by John Blacker, Mike Butters, Donna Blackmond, Peter Dunn, David Dale, Ian Mcconvey, Mike Monteith, Simon Hamilton, Kevin Roberts, Bob Docherty, Steve Mcghie, John Atherton, Suju Mathew, Trevor Laird, John Carey, David Laffan, Nick Thomson, Michael T. Williams, Mike T. Williams, David Fox, Rsc Publishing, David E. Thurston, David P. Rotella, Ana Martinez, Salvatore Guccione, Professor Robin Ganellin, Robin Ganellin Hardcover, 374 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-146-1, ISBN: 1-84973-146-2 "Pharmaceutical process research and development is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects ..." |
 | | Preclinical Drug Discovery(1st Edition) Complete Set (RSC Drug Discovery) by Sheraz Gul, David E. Thurston, David Fox, David Rotella, Ana Martinez Hardcover, 900 Pages, Published 2014 by Royal Society Of Chemistry ISBN-13: 978-1-84973-243-7, ISBN: 1-84973-243-4 "This is a three-volume set that provides theoretical, practical and troubleshooting guidelines on all aspects of the pre-clinical Drug Discovery process. There is particular focus on the design, development and role of screening assays in Drug Discovery, including new developments and future trends, the main assay types utilized in screening campaigns, and the methods utilized in enabling the progression of ""Hits"" to ""Leads"" and ""C ..." |
 | | Comprehensive Biomarker Discovery and Validation for Clinical Application(1st Edition) RSC (RSC Drug Discovery) by Rainer Bischoff, Peter Horvatovich, David E. Thurston, Isabelle Fournier, Huub Hoefsloot, Eleftherios P. Diamandis, Michel Salzet, Peter Juhasz, Pascal Puchois, Natalia Govorukhina, Bruno Domon, Berend Hoekman, Christoph Borchers, Scott Napper, Alain Van Gool, Melissa A. Thompson, David P. Rotella, David Fox, Eleftherios Diamandis, Ana Martinez, Salvatore Guccione, Professor Robin Ganellin Hardcover, 384 Pages, Published 2013 by Royal Society Of Chemistry ISBN-13: 978-1-84973-422-6, ISBN: 1-84973-422-4 "Comprehensive Biomarker Discovery and Validation for Clinical Application provides the reader with an extensive introduction into all aspects of proteomics biomarker discovery, validation and development. It discusses the current status of science and technology, its limitations, bottlenecks as well as future development trends to improve the success rate of translating biomarker discovery into useful clinical tests. The most important ..." |
 | | Computational Approaches to Nuclear Receptors(1st Edition) From Computational Simulation to In Vivo Experiments (RSC Drug Discovery) by Pietro Cozzini, Glen E. Kellogg, Stefano Lorenzetti, David E. Thurston, Laura Narciso, Xavier Barril, Francesca Spyrakis, Ruben Abagyan, Yan Zhang, Chris Arnatt, Chiara Dall'asta, Andrea Faccini, Gianni Galverna, Agostino Dovier, Javier Luque, Ernesto Pontelli, Adriana Maggi, Irina Kufareva, Martin Safo, Michael Appell, Wayne B. Bosma, Alessandro Dal Palu, David P. Rotella, Ana Martinez, Salvatore Guccione, Professor Robin Ganellin, David Fox Hardcover, 176 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-364-9, ISBN: 1-84973-364-3 "Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several "omics" projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization o ..." |
 | | Extracellular and Intracellular Signaling(1st Edition) RSC (RSC Drug Discovery) by Keith Parker, James D. Adams, Eric J. Lien, Mary Sugden, David E. Thurston, Oreste Gualillo, Morris Karmazyn, Philip Atherton, Gary Goldberg, Lori Klaidman, William Goddard, Mark J. Holness, M. A. Sortino, Fernando Cardozo-Pelaez, Ana Martinez, Salvatore Guccione, David P. Rotella, Professor Robin Ganellin, David Fox, Jane Doe Hardcover, 303 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-160-7, ISBN: 1-84973-160-8 "Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. They are causative agents for diseases including hypertension, diabetes, heart disease, and arthritis so offer new, and often more approachable, targets for drug design. Aimed at medical professionals and pharmaceutical ..." |
 | | New Synthetic Technologies in Medicinal Chemistry(1st Edition) RSC (RSC Drug Discovery) by Elizabeth Farrant, Andrew Merritt, Brian Warrington, Andrew Morrell, Martyn Deal, Rachel Osborne, David Fox, Steven V. Ley, David E. Thurston, Jon Roffey, Mark Bagley, David P. Rotella, Ana Martinez, Salvatore Guccione Hardcover, 176 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-017-4, ISBN: 1-84973-017-2 "The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. It covers both synthetic technologies currently impacting medicinal chemistry and emerging areas. The chapters focus on topics including: parallel medicinal chemistry; solid supported reagent ..." |
 | | Drug Discovery for Schizophrenia(1st Edition) (RSC Drug Discovery) by Tatiana V. Lipina, John C. Roder, Albert Wong, Peter Gebicke-Haerter, Raul Gainetdinov, Amy Ramsey, Urs Meyer, David Thurston, Ana Martinez, John Waddington, Inna Gaisler-Salomon, Nick Brandon, Bernard Lefoll, Fang Liu, Dennis Kaetzel, Martin Beaulieu Hardcover, 289 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-78262-026-6, ISBN: 1-78262-026-5 "Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a c ..." |
 | | Ion Channel Drug Discovery(1st Edition) RSC (RSC Drug Discovery) by Brian Cox, Martin Gosling, William Catterall, Martin J. Main, John Mitcheson, Simon Ward, David N. Sheppard, E. Palant, Donald L. Gill, Catherine Howsham, Henry Danahay, Mark Nash, Alan D. Wickenden, Phillip J. Stansfeld, C. Faltynek, John Dunlop Md, David E. Thurston, Stephen Hess, Brian Cox Dr, David P. Rotella, David Fox, Matthias Dietz, Ana Martinez, Salvatore Guccione, Professor Robin Ganellin, Robin Ganellin Hardcover, 384 Pages, Published 2014 by Royal Society Of Chemistry ISBN-13: 978-1-84973-186-7, ISBN: 1-84973-186-1 "Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book ..." |
 | | Drug Discovery from Natural Products (RSC Drug Discovery) by Olga Genilloud, Francisca Vicente, Ana Martinez, Carmen Cuevas, Andres Francesch, Markus Kalesse, Roderich Sussmuth, Andreas Kirschning, Guy Carter, Lynette A. Smyth Hardcover, 1 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-495-0, ISBN: 1-84973-495-X "This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of cas ..." |
 | | Anti-Inflammatory Drug Discovery(1st Edition) RSC (RSC Drug Discovery) by Jeremy I. Levin, Stefan Laufer, Nathan Tumey, Wolfgang Albrecht, Atli Thorarensen, Neelu Kaila, Michael Skynner, Phil Jeffrey, Michael Binks, Michael Woodrow, Erick Young, Mark Schnute, Robert Merritt, Annette Gilchrist, Matthias Lehr, Oliver Werz, David Rotella, Cheri Grice, Robert V. Talanian, Jeremy J. Edmunds, Zhihua Sui, Cuifen Hou, Eric Gilbert, Craig Miller, David Augeri, Tamas Oravecz, Hossein Razavi, Christian Harcken, David E. Thurston, David Fox, Ana Martinez, Salvatore Guccione, Professor Robin Ganellin, Robin Ganellin, Jane Doe Hardcover, 528 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-413-4, ISBN: 1-84973-413-5 "Anti-Inflammatory Drug Discovery provides a comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and provides a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action. The editors, with extensive experience in this field, have selected key thought-leaders who will bring their experience to the medici ..." |
 | | Designing Multi-Target Drugs(1st Edition) RSC (RSC Drug Discovery) by J. Richard Morphy, C. John Harris, Mo Shahid, Jorrit Hornberg, Malcolm Young, Michael Keiser, Jon Mason, Andrew Hopkins, Janet Dancey, Xiong Cai, Karen Lackey, Natesan Murugesan, David P. Rotella, Y. Z. Chen, Christopher A. Lipinski, John A. Lowe, Robert J. Weikert, Carlos Garcia-Echeverria, Michael D. Wendt, Maria Laura Bolognesi, Stephen P. East, Giulio Superti-Furga, David E. Thurston, David Fox, Ana Martinez, Salvatore Guccione Hardcover, 394 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-362-5, ISBN: 1-84973-362-7 "Multi-target drug discovery (MTDD) is an emerging area of increasing interest to the drug discovery community. Drugs that modulate several targets have the potential for an improved balance of efficacy and safety compared to single targets agents. Although there are a number of marketed drugs that are thought to derive their therapeutic benefit by virtue of interacting with multiple targets, the majority of these were discovered acciden ..." |
 | | Kinase Drug Discovery(1st Edition) RSC (RSC Drug Discovery) by Frederick Goldberg, Richard A. Ward, Andrew Wilks, Kevin Guertin, Walter Ward, Jack Bikker, Jeroen Verheijen, Martin Swarbrick, David P. Rotella, Carlos Garcia-Echeverria, Iain Simpson, Andrew J. Ratcliffe, David H. Drewry, Cancer Research Uk, David E. Thurston, David Fox, Ana Martinez, Salvatore Guccione, Richard Andrew Ward, Noel Southall, Frederick Woolf Goldberg Hardcover, 332 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-174-4, ISBN: 1-84973-174-8 "Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small molecule drugs which target kinases and many more compounds in various stages of clinical development. Although there have been a number of reviews/publications on kinase research, this book fills a gap in the literature by considering the current and future opportunities and challe ..." |
 | | Carbohydrates in Drug Design and Discovery(1st Edition) (RSC Drug Discovery) by Jesus Jimenez-Barbero, Sonsoles Martin-Santamaria, Marco Marradi, Xuefei Huang, Alba Silipo, Soledad Penades, F. Javier Canada, David Thurston, Ana Martinez, Antonio Molinaro, Frank Schweizer, Laurence Mulard, Amelia Pilar Rauter, Cristina Nativi, Timor Baasov, Vicente Verez Bencomo, Aloysius Siriwardena, Ben Davis, Rene Roy, Stéphane Vincent, Jérôme Nigou Hardcover, 320 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-84973-939-9, ISBN: 1-84973-939-0 "In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in th ..." |
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