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  | | G Protein-Coupled Receptors(1st Edition) From Structure to Function (RSC Drug Discovery) by Jesus Giraldo, Jean-Philippe Pin, Krzysztof Palczewski, Gebhard Schertler, Ana Martinez, Francisco Ciruela, Stefano Costanzi, Marta Filizola, Michel Bouvier, Debbie Hay, Terry Kenakin, Martin Lohse, Vsevolod V. Gurevich, Joël Bockaert, Pablo Escribá, Jean-Pierre Vilardaga, Thomas P. Sakmar, Robert J. Lefkowitz, Federico Mayor Jnr, Milton T. Stubbs, Jonathon A. Javitch, Oliver P. Ernst, Jennifer Linderman, Roger Sunahara, Graeme Milligan, Steven O. Smith, David E. Shaw, David E. Thurston, Franciso Ciruela, Dr. Jean-Pierre Vilardaga, Rsc Publishing, Pablo V. Escribß, Jane Doe, Joùl Bockaert, Casanelia L. Hardcover, 548 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-183-6, ISBN: 1-84973-183-7 "G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, pept ..." |
 | | Neglected Diseases and Drug Discovery(1st Edition) RSC (RSC Drug Discovery) by Michael J. Palmer, Jonathan Vennerstrom, Meg Phillips, Arnab Chatterjee, Simon Croft, Bob Jacobs, John Overington, Debra Hanna, Thomas Keller, Tim Geary, Elna Ryst, David Brown, Win Gutteridge, Simon Campbell, Jeremy N. Burrows, Mark Mitton-Fry, J. Carl Craft, David Fox, Mike Palmer, Rsc Publishing, Ana Martinez, David E. Thurston, Salvatore Guccione, David P. Rotella, Professor Robin Ganellin 438 Pages, Published 2012 by Rsc ISBN-13: 978-1-84973-192-8, ISBN: 1-84973-192-6 "There are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas th ..." |
 | | New Horizons in Predictive Toxicology(1st Edition) Current Status and Application (RSC Drug Discovery) by Chihae Yang, Makoto Hayashi, Andrew Worth, Scott Boyer, Mark Cronin, Robert Daniel Benz, Nigel Greene, Xuemei Liu, Patricia Escobar, Vic Kadambi, James Mckim, Albert Li, Alison Vickers, Yvonne Will, Jeff Kramer, Robert Tanguay, Michael Schlosser, Carl Alden, Tim Masiasz, Michael Gralinski, Tom Kawabata, William Mattes, Ann Richard, David P. Rotella, William R. Kelce, Gordon Hard, F. Peter Guengerich, Yuichi Sugiyama, Hiroyuki Kusuhara, Dennis A. Smith, Melvin Anderson, Robert A. Roth, P. Vogel, R. Read, David E. Thurston, Rsc Publishing, Alan G. Wilson, Jane Doe Hardcover, 732 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-051-8, ISBN: 1-84973-051-2 "Modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of great importance. Such approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technolog ..." |
 | | Accounts in Drug Discovery(1st Edition) Case Studies in Medicinal Chemistry (RSC Drug Discovery) by Joel C. Barrish, Percy H. Carter, Robert Zahler, Peter Cheng, Bruce Rogers, Christopher Barber, Jeffrey Robl, Mark Norman, Lyn Jones, Gavin Whitlock, Mark Andrews, Mark Mulvihill, Richard Mackman, Edmund Graziani, Phil Hamann, Mike Sofia, Samuel Chackalamannil, Ramakanth Sarabu, David P. Rotella, Michael J. Palmer, Ashvinikumar V. Gavai, David Fox, Ana Martinez, Salvatore Guccione, David E. Thurston, Rsc Publishing Hardcover, 370 Pages, Published 2010 by Royal Society Of Chemistry ISBN-13: 978-1-84973-126-3, ISBN: 1-84973-126-8 "Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" ..." |
 | | Fragment-Based Drug Discovery (RSC Drug Discovery) by Dr. Steven Howard, Chris Abell, David Thurston, Harren Jhoti, Martin Drysdale, Daniel A. Erlanson, Tony Giannetti, Isabelle Krimm, Michael Hann, Peter Kutchukian Digital, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-78262-093-8, ISBN: 1-78262-093-1 "Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written f ..." |
 | | Drug Discovery for Schizophrenia(1st Edition) (RSC Drug Discovery) by Tatiana V. Lipina, John C. Roder, Albert Wong, Peter Gebicke-Haerter, Raul Gainetdinov, Amy Ramsey, Urs Meyer, David Thurston, Ana Martinez, John Waddington, Inna Gaisler-Salomon, Nick Brandon, Bernard Lefoll, Fang Liu, Dennis Kaetzel, Martin Beaulieu Hardcover, 289 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-78262-026-6, ISBN: 1-78262-026-5 "Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a c ..." |
 | | Drug Transporters(1st Edition) Volume 1: Role and Importance in ADME and Drug Development (RSC Drug Discovery) by Glynis Nicholls, Kuresh Youdim, David Dickens, Susan Cole, Nick Plant, Bente Steffansen, Professor Pradeep Sharma, John Keogh, Bruno Stieger, Lena Gustavsson, Nico Scheer, Varma Manthena, Silke Simon, Ichiro Leiri, David Marcus, Karelle Menochet, Aki Heikkinen, Git W. Chung, David Thurston, David Fox, Colin Brown, Hideyuki Saito Hardcover, 577 Pages, Published 2016 by Royal Society Of Chemistry ISBN-13: 978-1-78262-069-3, ISBN: 1-78262-069-9 "Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, ..." |
 | | Synthetic Methods in Drug Discovery(1st Edition) Complete Set (RSC Drug Discovery) by David Blakemore, Yvette Fobian, Paul Doyle, David Thurston, David Fox, Paul Doyle Jr Hardcover, 1,010 Pages, Published 2016 by Royal Society Of Chemistry ISBN-13: 978-1-78262-787-6, ISBN: 1-78262-787-1 "The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. This two-volume set of books provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reac ..." |
 | | Drug Transporters Volume 2: Recent Advances and Emerging Technologies (RSC Drug Discovery) by Glynis Nicholls, Bruno Stieger, Hideyuki Saito, David Dickens, Lena Gustavsson, Nico Scheer, Professor Pradeep Sharma, Varma Manthena, Silke Simon, Susan Cole, Nick Plant, Ichiro Leiri, David Marcus, Bente Steffansen, Karelle Menochet, John Keogh, Aki Heikkinen, Colin Brown, Kuresh Youdim, David Fox, Dr Kuresh Youdim, David Thurston Hardcover, 239 Pages, Published 2016 by Royal Society Of Chemistry ISBN-13: 978-1-78262-866-8, ISBN: 1-78262-866-5 "Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential are ..." |
 | | Privileged Scaffolds in Medicinal Chemistry(1st Edition) Design, Synthesis, Evaluation (RSC Drug Discovery) by Stefan Bräse, Arantxa Encinas, Carmen Gil, Kye Masters, Dr Roland Pfau, David Thurston, Ana Martinez, Dorota Jakubczyk, Carsten S. Kramer, David Newman, Frederico Albericio, Henning Steinhagen, Lucija Peterlin Masic, Shahriar Mobashery, Eliezer J. Barreiro, Wolfgang Wenzel, Mayland Chang, Esther Rösch, Franziska Gläser, Babbs Liz Hardcover, 486 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-78262-030-3, ISBN: 1-78262-030-3 "One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it no ..." |
 | | Green Chemistry Strategies for Drug Discovery(1st Edition) (RSC Drug Discovery) by Julie B. Manley, Emily A. Peterson, David Thurston, Helen Sneddon, Leanna Shuster, Larry Miller, Paul Richardson, B. Frank Gupton, Kristi Budzinski, Daniel Richter, Alex Clark, Nichloas Anastas, David Taylor, Andrew Cohen, Andrew Trask, Joe Fortunak Hardcover, 347 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-84973-961-0, ISBN: 1-84973-961-7 "The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at ear ..." |
 | | Cardiovascular and Metabolic Disease(1st Edition) Scientific Discoveries and New Therapies (RSC Drug Discovery) by Philip Peplow, James Adams, Tim Young, Joseph Cornicelli, Rhian M. Touyz, Theodore Kotchen, Rinki Murphy, Andrew Swick, David Thurston, Steve Vickers, Elnaz Menhaji-Klotz, Diler Aslan, Kirsten Coppell, Shahrad Taheri, Geoffrey Head, Jeffrey Stephens Hardcover, 405 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-78262-046-4, ISBN: 1-78262-046-X "Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book brings together the recent information on these disorders and the links that exist between them in order to provide a complete picture of drug discovery for these conditions. The main three sections comprehensively discuss obesity, hypertension and cardiovascular d ..." |
 | | Carbohydrates in Drug Design and Discovery(1st Edition) (RSC Drug Discovery) by Jesus Jimenez-Barbero, Sonsoles Martin-Santamaria, Marco Marradi, Xuefei Huang, Alba Silipo, Soledad Penades, F. Javier Canada, David Thurston, Ana Martinez, Antonio Molinaro, Frank Schweizer, Laurence Mulard, Amelia Pilar Rauter, Cristina Nativi, Timor Baasov, Vicente Verez Bencomo, Aloysius Siriwardena, Ben Davis, Rene Roy, Stéphane Vincent, Jérôme Nigou Hardcover, 320 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-84973-939-9, ISBN: 1-84973-939-0 "In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in th ..." |
 | | Synthetic Methods in Drug Discovery(1st Edition) Volume 1 (RSC Drug Discovery) by David C. Blakemore, Paul M. Doyle, Yvette M. Fobian, Chris Limberakis, Lee Boulton, Alpay Dermenci, Kevin Hesp, Nuria Rodriguez-Garrido, Brian Gerstenberger, Scott Sutton, Daniel Copley Schmitt, Anne-Marie Schmitt, Peter D. Smith, Paul Richardson, Jonathan Williams, Joseph Warmus, Damien Webb, Brian T. O'neill, David Thurston, David Fox, Doyle Fo Blakemore, Damian Webb, Patrick Lam, President Brian O'neill Hardcover, 474 Pages, Published 2016 by Royal Society Of Chemistry ISBN-13: 978-1-84973-803-3, ISBN: 1-84973-803-3 "Synthetic Methods in Drug Discovery Volume 1 focusses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic ..." |
 | | Synthetic Methods in Drug Discovery Volume 2 (RSC Drug Discovery) by David C. Blakemore, Paul M. Doyle, Yvette M. Fobian, Chris Limberakis, Lee Boulton, Alpay Dermenci, Kevin Hesp, Damian Webb, Nuria Rodriguez-Garrido, Brian Gerstenberger, Scott Sutton, Daniel Copley Schmitt, Anne-Marie Schmitt, Peter D. Smith, Paul Richardson, Jonathan Williams, Joseph Warmus, David Thurston, David Fox, Brian T. O'neill, Patrick Lam, President Brian O'neill Hardcover, 517 Pages, Published 2016 by Royal Society Of Chemistry ISBN-13: 978-1-78262-786-9, ISBN: 1-78262-786-3 "Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods to access novel motifs and monomers. This book provides both academic and in ..." |
 | | Name Reactions(1st Edition) A Collection of Detailed Mechanisms and Synthetic Applications Fifth Edition by Steven Howard, Chris Abell, Harren Jhoti, Martin Drysdale, Daniel A. Erlanson, Tony Giannetti, Isabelle Krimm, Peter Kutchukian, Dr Michael Hann, David Thurston, Terry Hughes Msc, Christina Spry, Iwan De Esch, Miles Congreve, Roderick Hubbard, Paul Bamborough, Abell Howard Hardcover, 264 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-84973-908-5, ISBN: 1-84973-908-0 "Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written ..." |
 | | BIOMEDICAL IMAGING(1st Edition) THE CHEMISTRY OF LABELS, PROBES AND CONTRAST AGENTS [Hardcover] Martin Braddock by Martin Braddock, David Rotella, David Thurston, John Waterton, Fabian Kiessling, Erno Brucher, Jenghwa Chang, Eric Solon, Nicolau Beckmann, Klaus Suhling, Richard Hargreaves, Gilles Tamagnan, Kumar Changani, Darren Macfarland, Xiaoyuan Chen, Chun-Ru Wang, Robert Hanson, Pier Lucio Anelli, Paul Garside, David Fox, Ana Martinez, Salvatore Guccione, Anthony Gee, David J. Goldberg Hardcover, 552 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-014-3, ISBN: 1-84973-014-8 "The focus of this new book is for medicinal chemists on the chemical agents that have been used, or might be required in the future, and the methods of synthesis for inserting the reporter groups. Medicinal chemists need to know the critical issues involved in using such chemical agents with regard to the biological applications - for instance - what properties are needed chemically and why? The topics covered in the book are: PET, SPEC ..." |
 | | A Brief History Of Winthrop, From 1764 To October 1855 by David Thurston Hardcover, 248 Pages, Published 2010 by Kessinger Publishing ISBN-13: 978-1-164-73700-1, ISBN: 1-164-73700-7 "This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare an ..." |
 | | A Sermon Preached At The Ordination Of The Reverend Josiah Tucker, Over The Congregational Church And Society In Madison by David Thurston Hardcover, 20 Pages, Published 2010 by Kessinger Publishing ISBN-13: 978-1-169-38844-4, ISBN: 1-169-38844-2 |
 | | A Sermon Preached At The Ordination Of The Reverend Josiah Tucker, Over The Congregational Church And Society In Madison by David Thurston Paperback, 20 Pages, Published 2009 by Kessinger Publishing ISBN-13: 978-1-120-12977-2, ISBN: 1-120-12977-X |
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