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  | | Polyamine Drug Discovery(1st Edition) RSC (RSC Drug Discovery) by Patrick M. Woster, Robert Anthony Casero, Steven Ealick, Nigel Yarlett, Otto Phanstiel, Andre Bachmann, Robert Casero, Andrew Goodwin, Ian S. Blagbrough, Nicholas P. Farrell, David Rotella, Lawrence J. Marton, Anthony E. Pegg, Yi Huang Dr, Yi Huang, David P. Rotella, David E. Thurston, Rsc Publishing Hardcover, 302 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-190-4, ISBN: 1-84973-190-X "Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first compre ..." |
 | | Preclinical Drug Discovery(1st Edition) High Throughput Screening and Compound Progression Strategies (RSC Drug Discovery) by Sheraz Gul, Namir Hassan, David Rotella, David E. Thurston, Mike Trevethick, Rsc Publishing Hardcover, 288 Pages, Published 2014 by Royal Society Of Chemistry ISBN-13: 978-1-84973-134-8, ISBN: 1-84973-134-9 "This book is one of a three-volume set that provides theoretical, practical and troubleshooting guidelines on all aspects of the pre-clinical Drug Discovery process. There is particular focus on the design, development and role of screening assays in Drug Discovery, including new developments and future trends, the main assay types utilized in screening campaigns, and the methods utilized in enabling the progression of ""Hits"" to ""L ..." |
 | | Neglected Diseases and Drug Discovery(1st Edition) RSC (RSC Drug Discovery) by Michael J. Palmer, Jonathan Vennerstrom, Meg Phillips, Arnab Chatterjee, Simon Croft, Bob Jacobs, John Overington, Debra Hanna, Thomas Keller, Tim Geary, Elna Ryst, David Brown, Win Gutteridge, Simon Campbell, Jeremy N. Burrows, Mark Mitton-Fry, J. Carl Craft, David Fox, Mike Palmer, Rsc Publishing, Ana Martinez, David E. Thurston, Salvatore Guccione, David P. Rotella, Professor Robin Ganellin 438 Pages, Published 2012 by Rsc ISBN-13: 978-1-84973-192-8, ISBN: 1-84973-192-6 "There are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas th ..." |
 | | New Horizons in Predictive Toxicology(1st Edition) Current Status and Application (RSC Drug Discovery) by Chihae Yang, Makoto Hayashi, Andrew Worth, Scott Boyer, Mark Cronin, Robert Daniel Benz, Nigel Greene, Xuemei Liu, Patricia Escobar, Vic Kadambi, James Mckim, Albert Li, Alison Vickers, Yvonne Will, Jeff Kramer, Robert Tanguay, Michael Schlosser, Carl Alden, Tim Masiasz, Michael Gralinski, Tom Kawabata, William Mattes, Ann Richard, David P. Rotella, William R. Kelce, Gordon Hard, F. Peter Guengerich, Yuichi Sugiyama, Hiroyuki Kusuhara, Dennis A. Smith, Melvin Anderson, Robert A. Roth, P. Vogel, R. Read, David E. Thurston, Rsc Publishing, Alan G. Wilson, Jane Doe Hardcover, 732 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-051-8, ISBN: 1-84973-051-2 "Modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of great importance. Such approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technolog ..." |
 | | Accounts in Drug Discovery(1st Edition) Case Studies in Medicinal Chemistry (RSC Drug Discovery) by Joel C. Barrish, Percy H. Carter, Robert Zahler, Peter Cheng, Bruce Rogers, Christopher Barber, Jeffrey Robl, Mark Norman, Lyn Jones, Gavin Whitlock, Mark Andrews, Mark Mulvihill, Richard Mackman, Edmund Graziani, Phil Hamann, Mike Sofia, Samuel Chackalamannil, Ramakanth Sarabu, David P. Rotella, Michael J. Palmer, Ashvinikumar V. Gavai, David Fox, Ana Martinez, Salvatore Guccione, David E. Thurston, Rsc Publishing Hardcover, 370 Pages, Published 2010 by Royal Society Of Chemistry ISBN-13: 978-1-84973-126-3, ISBN: 1-84973-126-8 "Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" ..." |
 | | Stem Cells Regenerative Pharmacology, Drug Discovery and Development (RSC Drug Discovery) by Timothy Allsopp, G. Sitta Sittampalam, David E. Thurston, David Fox, David Rotella, Tim Allsopp Hardcover, 400 Pages, Published 2014 by Royal Society Of Chemistry ISBN-13: 978-1-84973-173-7, ISBN: 1-84973-173-X |
 | | Macrocycles in Drug Discovery(1st Edition) (RSC Drug Discovery) by Jeremy I. Levin, David Newman, A. Ganesan, Anders Poulsen, Michael Burnet, David Fairlie, Daniel Obrecht, Eric Feyfant, Wieslaw M. Kazmierski, Alan Mathiowetz, Dr Mark Peterson, David Rotella, Karl-Heinz Altmann, David P. Rotella Hardcover, 528 Pages, Published 2014 by Royal Society Of Chemistry ISBN-13: 978-1-84973-701-2, ISBN: 1-84973-701-0 "This book will review macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. A variety of macrocyclic natural products have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds in the context of their broad chemotype as compounds composed of l ..." |
 | | Inhibitors of Molecular Chaperones as Therapeutic Agents(1st Edition) RSC (RSC Drug Discovery) by Timothy D. Machajewski, Zhenhai Gao, David P. Rotella, Chrisostomos Prodromou, Paul Workman, Marco Biamonte, Weiwen Ying, Pamela Mclean, Lila M. Gierasch, Tim Haystead, Michael Ruggard-Jensen, Brian Blagg, Wenlai Zhou, Len Neckers, Emin Avsar, Utpal Tatu, Didier Picard, David Rotella, Gao Machajewski Hardcover, 442 Pages, Published 2013 by Royal Society Of Chemistry ISBN-13: 978-1-84973-666-4, ISBN: 1-84973-666-9 "This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad ..." |
 | | Anti-Inflammatory Drug Discovery(1st Edition) RSC (RSC Drug Discovery) by Jeremy I. Levin, Stefan Laufer, Nathan Tumey, Wolfgang Albrecht, Atli Thorarensen, Neelu Kaila, Michael Skynner, Phil Jeffrey, Michael Binks, Michael Woodrow, Erick Young, Mark Schnute, Robert Merritt, Annette Gilchrist, Matthias Lehr, Oliver Werz, David Rotella, Cheri Grice, Robert V. Talanian, Jeremy J. Edmunds, Zhihua Sui, Cuifen Hou, Eric Gilbert, Craig Miller, David Augeri, Tamas Oravecz, Hossein Razavi, Christian Harcken, David E. Thurston, David Fox, Ana Martinez, Salvatore Guccione, Professor Robin Ganellin, Robin Ganellin, Jane Doe Hardcover, 528 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-413-4, ISBN: 1-84973-413-5 "Anti-Inflammatory Drug Discovery provides a comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and provides a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action. The editors, with extensive experience in this field, have selected key thought-leaders who will bring their experience to the medici ..." |
 | | Preclinical Drug Discovery(1st Edition) Biochemical Methods in High Throughput Screening (RSC Drug Discovery) by Sheraz Gul, David Rotella, David E. Thurston Hardcover, 256 Pages, Published 2015 by Royal Society Of Chemistry ISBN-13: 978-1-84973-139-3, ISBN: 1-84973-139-X "This book provides theoretical, practical and troubleshooting guidelines on biochemical methods in high-throughput screening as part of the pre-clinical Drug Discovery process. There is particular focus on the design, development and role of screening assays in Drug Discovery, including new developments and future trends, the main assay types utilized in screening campaigns, and the methods utilized in enabling the progression of "Hits" ..." |
 | | Preclinical Drug Discovery(1st Edition) Complete Set (RSC Drug Discovery) by Sheraz Gul, David E. Thurston, David Fox, David Rotella, Ana Martinez Hardcover, 900 Pages, Published 2014 by Royal Society Of Chemistry ISBN-13: 978-1-84973-243-7, ISBN: 1-84973-243-4 "This is a three-volume set that provides theoretical, practical and troubleshooting guidelines on all aspects of the pre-clinical Drug Discovery process. There is particular focus on the design, development and role of screening assays in Drug Discovery, including new developments and future trends, the main assay types utilized in screening campaigns, and the methods utilized in enabling the progression of ""Hits"" to ""Leads"" and ""C ..." |
 | | Preclinical Drug Discovery(1st Edition) Cell-Based Methods in High Throughput Screening (RSC Drug Discovery) by Sheraz Gul, David Rotella, David E. Thurston Hardcover, 256 Pages, Published 2014 by Royal Society Of Chemistry ISBN-13: 978-1-84973-429-5, ISBN: 1-84973-429-1 "This book is one of a three-volume set that provides theoretical, practical and troubleshooting guidelines on all aspects of the pre-clinical Drug Discovery process. There is particular focus on the design, development and role of screening assays in Drug Discovery, including new developments and future trends, the main assay types utilized in screening campaigns, and the methods utilized in enabling the progression of ""Hits"" to ""Lea ..." |
 | | Successful Strategies for the Discovery of Antiviral Drugs(1st Edition) RSC (RSC Drug Discovery) by Manoj C. Desai, Nicholas A. Meanwell, David E. Thurston, Makonen Belema, David Sperandio, Randall Halcomb, Christopher Roberts, Lianhong Xu, Bill Guyer, Mike Sofia, Robert Jordan, Pei-Yong Shi, Stephen Griffin Dr, Salvatore Guccione, Ana Martinez, David Rotella, Brian A. Johns, Pierre L. Beaulieu, John A. Mccauley, Michael R. Peel, Professor Robin Ganellin, David Fox, Stephen Griffin Hardcover, 550 Pages, Published 2013 by Royal Society Of Chemistry ISBN-13: 978-1-84973-657-2, ISBN: 1-84973-657-X "The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is ..." |
 | | New Therapeutic Strategies for Type 2 Diabetes(1st Edition) Small Molecule Approaches (RSC Drug Discovery) by Rob M. Jones, David Rotella, Salvatore Guccione, Ana Martinez, David E. Thurston, J. Pfefferkorn, James Scott, Unmesh Shah, Robert Dow, Gang Liu, R. Pellicciari, Mark Erion, Geroge Vlasuk, Jonathan Houze, Duane Demong, Matthew Borbeau, Rongjun He, Yantao He, Zhong-Yin Zhang, Brad R. Henke, Li-Fan Zang, Kevin J. Filipski, Benjamin D. Stevens, Jasen Chooramun, Antonio Macchiarulo, Antimo Gioiello, Scott Edmondson, Jason Szewczyk, Daniel Cravo, Daniel Kemp, Zhonghua Pei, William Washburn, Robert Mark Jones, David Fox, Robin Ganellin, Professor Robin Ganellin, David P. Rotella Hardcover, 532 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-414-1, ISBN: 1-84973-414-3 "The diabetes mellitus epidemic is unfolding across the globe with the World Health Organization (WHO) reporting a worldwide prevalence of 177 million patients with diabetes. Type 2 diabetes accounts for approximately ninety percent of all diabetes cases. Long-term complications of type 2 diabetes include atherosclerosis, heart disease, stroke, end-stage renal disease, retinopathy leading to blindness, nerve damage, sexual dysfunction, f ..." |
 | | Drug Discovery for Psychiatric Disorders (RSC Drug Discovery) by Zoran Rankovic, Richard Hargreaves, Matilda Bingham, David Rotella, David Michelson, Kathryn Connor, Armin Szegedi, Mike Egan, John Morrow, Bruce Rogers Hardcover, 615 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-494-3, ISBN: 1-84973-494-1 "The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment of psychiatric patients and even our social perception of mental illnesses cannot be underestim ..." |
 | | Organic Chemistry of Drug Degradation(1st Edition) RSC (RSC Drug Discovery) by Min Li, David Rotella, Salvatore Guccione, Ana Martinez, David E. Thurston, David Fox, David P. Rotella Hardcover, 306 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-421-9, ISBN: 1-84973-421-6 "The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identific ..." |
 | | Comprehensive Medicinal Chemistry III Biologics medicine / vol. editors Ved Srivastava by Samuel Chackalamannil, David Rotella, Simon Edward Ward, Ana Martinez, Ved Srivastava, Carmen Gil, Helmut Buschmann, Norbert Handler, Andrea Wolkerstorfer, Andrew M. Davis, Colin Edge, Ian Collins, William Watkins, Louis J. Lombardo, Adrian Hall, Santhosh Neelamkavil, Rob Jones, Jörg Holenz 313 Pages, Published 2017 ISBN-13: 978-0-08-102245-0, ISBN: 0-08-102245-X |
 | | Comprehensive Medicinal Chemistry III Experimental ADME and toxicology / vol. editors Alan G. E. Wilson by Samuel Chackalamannil, David Rotella, Simon Edward Ward, Ana Martinez, Carmen Gil, Helmut Buschmann, Norbert Handler, Andrea Wolkerstorfer, Andrew M. Davis, Colin Edge, Ian Collins, William Watkins, Louis J. Lombardo, Ved Srivastava, Adrian Hall, Santhosh Neelamkavil, Rob Jones, Jörg Holenz 303 Pages, Published 2017 ISBN-13: 978-0-08-102243-6, ISBN: 0-08-102243-3 |
 | | Comprehensive Medicinal Chemistry III CNS, pain, metabolic syndrome, cardiovascular, tissue, fibrosis and urinary incontinence / vol. editors Adrian hall, Santhosh Neelamkavil, Rob Jones by Samuel Chackalamannil, David Rotella, Simon Edward Ward, Adrian Hall, Ana Martinez, Carmen Gil, Santhosh Neelamkavil, Helmut Buschmann, Rob Jones, Norbert Handler, Andrea Wolkerstorfer, Andrew M. Davis, Colin Edge, Ian Collins, William Watkins, Louis J. Lombardo, Ved Srivastava, Jörg Holenz 737 Pages, Published 2017 ISBN-13: 978-0-08-102246-7, ISBN: 0-08-102246-8 |